Bone marrow transplant trial to inform use of stem cell transplants for people with blood cancers
A national bone marrow transplant trial led by the Australian Centre for Blood Diseases (ACBD) at Monash University is investigating how to improve the survival of people with blood cancers who receive stem cell transplants.
Stem cell transplants have the potential to cure people with blood cancers, but around 20 per cent of transplant recipients succumb to graft-versus-host disease (GVHD), and better strategies are needed to prevent this complication.
Funded by the Medical Research Futures Fund, the research will include developing new genomic assays to detect patient-specific mutations and identifying biomarkers in patient samples.
The results of the five-year trial will be integrated into the Australian Bone Marrow Transplant Recipient Registry, which the ACBD research team anticipates will enhance transplant practice across Australia.
‘This trial will compare the impact of standard therapy against the stem cell transplant approach to inform more effective and efficient use of therapies for blood cancer,’ said Professor David Curtis, Head of Blood Cancer Research at the ACBD.