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Prostate cancer prevention one step closer with outcomes of landmark genetic research

Monash University’s Precision Medicine research group has discovered multiple new genetic risk factors that make men susceptible to aggressive prostate cancer in a landmark study that will contribute to future prevention of the disease.

Led by Dr Tu Nguyen-Dumont, the research group used gene panel sequencing to compare the genetic variants of 787 Australian men with aggressive prostate cancer and 769 men with non-aggressive prostate cancer. Further research compared gene variations in 920 men with either a strong family history of prostate cancer or the aggressive form of the disease.

The study used whole exome sequencing to discover 10 new genes associated with prostate cancer risk, with all but two of these connected with the aggressive form.

‘This new data will improve the care of men with and without prostate cancer, including the ability to predict susceptibility to aggressive prostate cancer and put in place measures to mitigate or even prevent the disease,’ said Dr Nguyen-Dumont.

The findings of this research were published in European Urology and the International Journal of Cancer and are the product of decades of collaborative research with Cancer Council Victoria’s Cancer Epidemiology Division.